Minipig in Biomedical Research

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The second edition of The Minipig in Biomedical Research is a comprehensive resource for research scientists on the use of the minipig in basic and applied biomedical research. The second edition includes full color throughout, with high-quality illustrations, making it the go-to guide and resource for users of minipigs.

The second edition of The Minipig in Biomedical Research is a comprehensive resource for research scientists on the use of the minipig in basic and applied biomedical research. Written by experts in the field, coverage extends from the minipig’s origins, anatomy, genetics, immunology, pathology and physiology to its welfare, health, and husbandry; practical dosing and examination procedures; surgical techniques; and all areas of toxicity testing and the uses of the minipig as a disease model. The book represents the state of the art, recognising the growing influence of Artificial Intelligence, and where appropriate, relevant databases are referenced. The future of minipigs with respect to genome editing and possible use in transplantation research makes this a very interesting model.

Since the first edition was published there has been a considerable increase in scientific, industrial and regulatory interest in the minipig; in some jurisdictions, for instance the UK, it is mandated that the minipig should be considered as a first-line non-rodent model. The expert authors in this new edition have given practical details and extensive examples of its successful application in many fields including surgery, drug development and safety testing. Greater emphasis is given to the origins and uses of several different strains of minipig, the greater understanding of genomics, genetic manipulation, immunology, their value in the development of novel exploratory and therapeutic implantable devices, and genetic and surgical procedures.

The second edition includes full color throughout, with high-quality illustrations, making it the go-to guide and resource for present and potential new users of minipigs.

Obsah

Chapter 0 Introduction Chapter 1 – The Göttingen Minipig Chapter 2 – Sinclair Nanopig Chapter 3 - The Yucatan minipig in research : A compendium Chapter 4 - The Ossabaw miniature pig Chapter 5 - The Bama minipig Chapter 6 – Husbandry and Management Chapter 7 – Diseases of minipigs Chapter 8 - Animal welfare standards around the world. AAALAC and beyond Chapter 9 - Common surgical procedures for minipigs Chapter 10 - Species selection for nonclinical programmes Chapter 11 - Regulatory aspects of the use of minipigs in the development of pharmaceuticals for human use Chapter 12 - Regulatory Acceptance of the Minipig in Non-Pharmaceutical Industry and Research Chapter 13 - The Minipig and Pig in Medical Device Research Chapter 14 - Dermal toxicology in the minipig : skin architecture, metabolism, penetration and toxicological and pharmacological methods Chapter 15 - The Gastrointestinal Tract Chapter 16 - Central and Peripheral Nervous Systems Chapter 17 - The kidney Chapter 18 – Skeletal system Chapter 19 - The minipig in regulatory guidelines for DART and juvenile toxicity studies Chapter 20 - The minipig eye as a model for preclinical toxicology Chapter 21 - Oral Biology and Dental Models Chapter 22 - The use of the minipig as a suitable species for inhalation administration Chapter 23 - The Minipig in Safety Pharmacology Chapter 24 - Spontaneous/background pathology of minipigs Chapter 25 - Immunological tools for minipig research Chapter 26 - Immunotoxicology Chapter 27 - Osteoporosis Model in Minipigs Chapter 28 - Use of minipigs in advanced therapy development Chapter 29 - Xenotransplantation Chapter 30 - Digital biomarkers and AI